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KMID : 0376419940180020133
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Chonbuk University Medical Journal
1994 Volume.18 No. 2 p.133 ~ p.138
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Effect of Cepharanthine on Treatment of Leukopenia Caused by Radiation Therapy
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권형철
김형진/김정수/김종훈/양두현
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Abstract
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Purpose:
@EN To investigate the hematopoietic effectiveness of cepharanthine on the treatment of leukopenia caused by radiation therapy(RT).
@ES Materials and Methods:
@EN 14 patients who developed leukopenia during RT enerted into trial. 10 of 14 patients took cepharanthine during RT(observed group) and 4 patients only received RT without cepharanthine treatment(control group). All patients received external
irradiation as standard fractionation of daily 180~200 cGy in 5 days per week. Oral intake of cepharanthine was started when leukocyte counts decreased below 4,000, continued until the end of RT. Daily dosage was 5mg. Drug effect was evaluated as
effective and no effective response according to change and recovery time(before 3 weeks after RT or less than 3,000 cGy) of leukocyte counts.
@ES Results:(1) Changes in leukocyte counts ; 1) Control group ; All patients appeared decrease of leukocyte counts from 1,000 cGy and recovery after 3,000 cGy. 2) Observed group ; Five of ten patients showed consistent increasing tendency and
recovery
before 3,000 cGy, One showed consistent increasing tendency but recovery appeared after 3,000 cGy, Four showed incosistent increasing tendency or no change or decreasing tendency, respectively, (2) Changes in platelet counts ; 1) Control group ;
All
patients appeared decrease of platelet counts from 1,000~2,000 cGy and recovery after 3,000~4,000 cGy. 2) Observed group ; Three of ten patients showed consistent or inconsistent increasing tendency after intake of cepharanthine. Five showed
decreasing
tendency and Two already showed increasing tendency before intake of cepharanthin. (3) Drug effect ; 5 of 10 patients showed effective response, 5 showed no effective response. (4) Comlication ; No toxicity was encountered.
@ES Conclusion:
@EN Our results suggest that cepharanthine is a effective and safe drug on treatment of leukopenia caused by RT.
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KEYWORD
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